And we will deliver free throughout The Netherlands or low-cost to any EU country.
We know you’re going to love Rooby bars, but we want to give you the option to try them before you commit to buying a full set.
Get your hands on one of our Try Out Boxes for just €9,95 and we’ll send you one of each delicious flavour.
Just drop your email in the box below to get your very own Try Out Box.
*price of 9,95€ is available for a limited time only and applies to one box per person..
Flaxseeds
Flaxseed is known for its health and beauty benefits. The nutrients found in flaxseed include healthy fats, lignans, fiber, antioxidants and other valuable vitamins and minerals.
Lignans
Jaafarnejad, F., Adibmoghaddam, E., Emami, S. A., & Saki, A. (2017). Compare the effect of flaxseed, evening primrose oil and Vitamin E on duration of periodic breast pain. Journal of education and health promotion, 6, 85. https://doi.org/10.4103/jehp.jehp_83_16
Mirghafourvand, M., Mohammad-Alizadeh-Charandabi, S., Ahmadpour, P., & Javadzadeh, Y. (2016). Effects of Vitex agnus and Flaxseed on cyclic mastalgia: A randomized controlled trial. Complementary therapies in medicine, 24, 90-95.
Adlercreutz, H., Höckerstedt, K., Bannwart, C., Bloigu, S., Hämäläinen, E., Fotsis, T., & Ollus, A. (1987). Effect of dietary components, including lignans and phytoestrogens, on enterohepatic circulation and liver metabolism of estrogens and on sex hormone binding globulin (SHBG). Journal of steroid biochemistry, 27(4-6), 1135-1144.
Nowak, D. A., Snyder, D. C., Brown, A. J., & Demark-Wahnefried, W. (2007). The effect of flaxseed supplementation on hormonal levels associated with polycystic ovarian syndrome: A case study. Current topics in nutraceutical research, 5(4), 177-181.
Farzana, F., Sulaiman, A., Ruckmani, A., Vijayalakshmi, K., Karunya Lakshmi, G., & Shri Ranjini, S. (2015). Effects of flax seeds supplementation in polycystic ovarian syndrome. Int J Pharm Sci Rev Res, 31(1), 113-119.
Mason, J. K., & Thompson, L. U. (2014). Flaxseed and its lignan and oil components: can they play a role in reducing the risk of and improving the treatment of breast cancer?. Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme, 39(6), 663–678. https://doi.org/10.1139/apnm-2013-0420
Lowcock, E. C., Cotterchio, M., & Boucher, B. A. (2013). Consumption of flaxseed, a rich source of lignans, is associated with reduced breast cancer risk. Cancer causes & control : CCC, 24(4), 813–816. https://doi.org/10.1007/s10552-013-0155-7
Nowak, D. A., Snyder, D. C., Brown, A. J., & Demark-Wahnefried, W. (2007). The effect of flaxseed supplementation on hormonal levels associated with polycystic ovarian syndrome: A case study. Current topics in nutraceutical research, 5(4), 177.
Adolphe, J. L., Whiting, S. J., Juurlink, B. H., Thorpe, L. U., & Alcorn, J. (2010). Health effects with consumption of the flax lignan secoisolariciresinol diglucoside. The British journal of nutrition, 103(7), 929–938. https://doi.org/10.1017/S0007114509992753
Magnesium
Facchinetti, F., Sances, G., Borella, P., Genazzani, A. R., & Nappi, G. (1991). Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache: The Journal of Head and Face Pain, 31(5), 298-301.
Allais, G., Gabellari, I. C., Burzio, C., Rolando, S., De Lorenzo, C., Mana, O., & Benedetto, C. (2012). Premenstrual syndrome and migraine. Neurological Sciences, 33(1), 111-115.
Fathizadeh, N., Ebrahimi, E., Valiani, M., Tavakoli, N., & Yar, M. H. (2010). Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iranian Journal of Nursing and Midwifery Research, 15(Suppl1), 401.
London, R. S., Bradley, L., & Chiamori, N. Y. (1991). Effect of a nutritional supplement on premenstrual symptomatology in women with premenstrual syndrome: a double-blind longitudinal study. Journal of the American College of Nutrition, 10(5), 494-499.
Quaranta, S., Buscaglia, M. A., Meroni, M. G., Colombo, E., & Cella, S. (2007). Pilot study of the efficacy and safety of a modified-release magnesium 250mg tablet (Sincromag®) for the treatment of premenstrual syndrome. Clinical drug investigation, 27(1), 51-58.
De Souza, M. C., Walker, A. F., Robinson, P. A., & Bolland, K. (2000). A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. Journal of women’s health & gender-based medicine, 9(2), 131-139.
Bendich, A. (2000). The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. Journal of the American college of nutrition, 19(1), 3-12.
Facchinetti, F., Borella, P., Sances, G., Fioroni, L., Nappi, R. E., & Genazzani, A. R. (1991). Oral magnesium successfully relieves premenstrual mood changes. Obstetrics and gynecology, 78(2), 177–181.
Walker, A. F., De Souza, M. C., Vickers, M. F., Abeyasekera, S., Collins, M. L., & Trinca, L. A. (1998). Magnesium supplementation alleviates premenstrual symptoms of fluid retention. Journal of women’s health, 7(9), 1157–1165. https://doi.org/10.1089/jwh.1998.7.1157
Chollet, D., Franken, P., Raffin, Y., Henrotte, J. G., Widmer, J., Malafosse, A., & Tafti, M. (2001). Magnesium involvement in sleep: genetic and nutritional models. Behavior genetics, 31(5), 413–425. https://doi.org/10.1023/a:1012790321071
Held, K., Antonijevic, I. A., Künzel, H., Uhr, M., Wetter, T. C., Golly, I. C., Steiger, A., & Murck, H. (2002). Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry, 35(4), 135–143. https://doi.org/10.1055/s-2002-33195
Lopez-Ridaura, R., Willett, W. C., Rimm, E. B., Liu, S., Stampfer, M. J., Manson, J. E., & Hu, F. B. (2004). Magnesium intake and risk of type 2 diabetes in men and women. Diabetes care, 27(1), 134–140. https://doi.org/10.2337/diacare.27.1.134
Larsson, S. C., & Wolk, A. (2007). Magnesium intake and risk of type 2 diabetes: a meta-analysis. Journal of internal medicine, 262(2), 208–214. https://doi.org/10.1111/j.1365-2796.2007.01840.x
Rodríguez-Morán, M., Simental Mendía, L. E., Zambrano Galván, G., & Guerrero-Romero, F. (2011). The role of magnesium in type 2 diabetes: a brief based-clinical review. Magnesium research, 24(4), 156–162. https://doi.org/10.1684/mrh.2011.0299
Kim, D. J., Xun, P., Liu, K., Loria, C., Yokota, K., Jacobs, D. R., Jr, & He, K. (2010). Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. Diabetes care, 33(12), 2604–2610. https://doi.org/10.2337/dc10-0994
Nielsen F. H. (2014). Effects of magnesium depletion on inflammation in chronic disease. Current opinion in clinical nutrition and metabolic care, 17(6), 525–530. https://doi.org/10.1097/MCO.0000000000000093
Barbagallo, M., & Dominguez, L. J. (2010). Magnesium and aging. Current pharmaceutical design, 16(7), 832–839. https://doi.org/10.2174/138161210790883679
Nielsen F. H. (2010). Magnesium, inflammation, and obesity in chronic disease. Nutrition reviews, 68(6), 333–340. https://doi.org/10.1111/j.1753-4887.2010.00293.x
Nielsen, F. H., Johnson, L. K., & Zeng, H. (2010). Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnesium research, 23(4), 158–168. https://doi.org/10.1684/mrh.2010.0220
Chacko, S. A., Sul, J., Song, Y., Li, X., LeBlanc, J., You, Y., Butch, A., & Liu, S. (2011). Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. The American journal of clinical nutrition, 93(2), 463–473. https://doi.org/10.3945/ajcn.110.002949
Vitamin B1
Chocano-Bedoya, P. O., Manson, J. E., Hankinson, S. E., Willett, W. C., Johnson, S. R., Chasan-Taber, L., Ronnenberg, A. G., Bigelow, C., & Bertone-Johnson, E. R. (2011). Dietary B vitamin intake and incident premenstrual syndrome. The American journal of clinical nutrition, 93(5), 1080–1086. https://doi.org/10.3945/ajcn.110.009530
Zafari, M., Aghamohammady, A., & Tofighi, M. (2011). Comparing the effect of vitamin B1 (vit. B1) and ibuberofen on the treatment of primary dysmenorrhea. Afr J Pharm Pharmacol, 5(7), 874-8.
Gokhale, L. B. (1996). Curative treatment of primary (spasmodic) dysmenorrhoea. The Indian journal of medical research, 103, 227-231.
Abdollahifard, S., & Maddahfar, M. (2016). The effects of vitamin B1 on ameliorating of mental symptoms of the premenstrual syndrome. European Psychiatry, (33), S335.
Almohanna, H. M., Ahmed, A. A., Tsatalis, J. P., & Tosti, A. (2019). The role of vitamins and minerals in hair loss: a review. Dermatology and therapy, 9(1), 51-70.
Plant based omega-3 fatty acid – alpha-linolenic acid (ALA) of which flaxseed is the richest plant source in the world!
Gebauer, S. K., Psota, T. L., Harris, W. S., & Kris-Etherton, P. M. (2006). n− 3 fatty acid dietary recommendations and food sources to achieve essentiality and cardiovascular benefits. The American journal of clinical nutrition, 83(6), 1526S-1535S.
Pan, A., Chen, M., Chowdhury, R., Wu, J. H., Sun, Q., Campos, H., Mozaffarian, D., & Hu, F. B. (2012). α-Linolenic acid and risk of cardiovascular disease: a systematic review and meta-analysis. The American journal of clinical nutrition, 96(6), 1262–1273. https://doi.org/10.3945/ajcn.112.044040
Blondeau, N., Lipsky, R. H., Bourourou, M., Duncan, M. W., Gorelick, P. B., & Marini, A. M. (2015). Alpha-linolenic acid: an omega-3 fatty acid with neuroprotective properties-ready for use in the stroke clinic?. BioMed research international, 2015, 519830. https://doi.org/10.1155/2015/519830
Blondeau N. (2016). The nutraceutical potential of omega-3 alpha-linolenic acid in reducing the consequences of stroke. Biochimie, 120, 49–55. https://doi.org/10.1016/j.biochi.2015.06.005
de Goede, J., Verschuren, W. M., Boer, J. M., Kromhout, D., & Geleijnse, J. M. (2011). Alpha-linolenic acid intake and 10-year incidence of coronary heart disease and stroke in 20,000 middle-aged men and women in the Netherlands. PloS one, 6(3), e17967. https://doi.org/10.1371/journal.pone.0017967
Simopoulos A. P. (2002). The importance of the ratio of omega-6/omega-3 essential fatty acids. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 56(8), 365–379. https://doi.org/10.1016/s0753-3322(02)00253-6
Jung, J. Y., Kwon, H. H., Hong, J. S., Yoon, J. Y., Park, M. S., Jang, M. Y., & Suh, D. H. (2014). Effect of dietary supplementation with omega-3 fatty acid and gamma-linolenic acid on acne vulgaris: a randomised, double-blind, controlled trial. Acta dermato-venereologica, 94(5), 521-526.
Goyal, A., Sharma, V., Upadhyay, N., Gill, S., & Sihag, M. (2014). Flax and flaxseed oil: an ancient medicine & modern functional food. Journal of food science and technology, 51(9), 1633–1653. https://doi.org/10.1007/s13197-013-1247-9
Fiber
Kristensen, M., Jensen, M. G., Aarestrup, J., Petersen, K. E., Søndergaard, L., Mikkelsen, M. S., & Astrup, A. (2012). Flaxseed dietary fibers lower cholesterol and increase fecal fat excretion, but magnitude of effect depend on food type. Nutrition & metabolism, 9, 8. https://doi.org/10.1186/1743-7075-9-8
Mani, U. V., Mani, I., Biswas, M., & Kumar, S. N. (2011). An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. Journal of dietary supplements, 8(3), 257–265. https://doi.org/10.3109/19390211.2011.593615
Mani, U. V., Mani, I., Biswas, M., & Kumar, S. N. (2011). An open-label study on the effect of flax seed powder (Linum usitatissimum) supplementation in the management of diabetes mellitus. Journal of dietary supplements, 8(3), 257–265. https://doi.org/10.3109/19390211.2011.593615
Nazni, P., Amrithaveni, M., & Poongodi, V. T. (2006). Impact of flaxseed based therapeutic food on selected type II diabetic patients. Indian J Nutr Diet, 43, 141-145.
Kajla, P., Sharma, A., & Sood, D. R. (2015). Flaxseed-a potential functional food source. Journal of food science and technology, 52(4), 1857–1871. https://doi.org/10.1007/s13197-014-1293-y
Thakur, G., Mitra, A., Pal, K., & Rousseau, D. (2009). Effect of flaxseed gum on reduction of blood glucose and cholesterol in type 2 diabetic patients. International journal of food sciences and nutrition, 60 Suppl 6, 126–136. https://doi.org/10.1080/09637480903022735
Saxena, S., & Katare, C. (2014). Evaluation of flaxseed formulation as a potential therapeutic agent in mitigation of dyslipidemia. Biomedical journal, 37(6), 386–390. https://doi.org/10.4103/2319-4170.126447
Patade, A., Devareddy, L., Lucas, E. A., Korlagunta, K., Daggy, B. P., & Arjmandi, B. H. (2008). Flaxseed reduces total and LDL cholesterol concentrations in Native American postmenopausal women. Journal of women’s health (2002), 17(3), 355–366. https://doi.org/10.1089/jwh.2007.0359
Ibrügger, S., Kristensen, M., Mikkelsen, M. S., & Astrup, A. (2012). Flaxseed dietary fiber supplements for suppression of appetite and food intake. Appetite, 58(2), 490–495. https://doi.org/10.1016/j.appet.2011.12.024
Kristensen, M., Savorani, F., Christensen, S., Engelsen, S. B., Bügel, S., Toubro, S., Tetens, I., & Astrup, A. (2013). Flaxseed dietary fibers suppress postprandial lipemia and appetite sensation in young men. Nutrition, metabolism, and cardiovascular diseases : NMCD, 23(2), 136–143. https://doi.org/10.1016/j.numecd.2011.03.004
Anderson, J. W., Baird, P., Davis, R. H., Jr, Ferreri, S., Knudtson, M., Koraym, A., Waters, V., & Williams, C. L. (2009). Health benefits of dietary fiber. Nutrition reviews, 67(4), 188–205. https://doi.org/10.1111/j.1753-4887.2009.00189.x
Amino Acids: Arginine & Glutamine
Gornik, H. L., & Creager, M. A. (2004). Arginine and endothelial and vascular health. The Journal of nutrition, 134(10 Suppl), 2880S–2895S. https://doi.org/10.1093/jn/134.10.2880S
Avenell A. (2006). Glutamine in critical care: current evidence from systematic reviews. The Proceedings of the Nutrition Society, 65(3), 236–241. https://doi.org/10.1079/pns2006498
Pumpkin seeds
Pumpkin seeds are an excellent source of magnesium, zinc, phytoestrogens and healthy fats that have been shown to provide numerous health benefits.
Magnesium
Facchinetti, F., Sances, G., Borella, P., Genazzani, A. R., & Nappi, G. (1991). Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache: The Journal of Head and Face Pain, 31(5), 298-301.
Allais, G., Gabellari, I. C., Burzio, C., Rolando, S., De Lorenzo, C., Mana, O., & Benedetto, C. (2012). Premenstrual syndrome and migraine. Neurological Sciences, 33(1), 111-115.
Fathizadeh, N., Ebrahimi, E., Valiani, M., Tavakoli, N., & Yar, M. H. (2010). Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iranian Journal of Nursing and Midwifery Research, 15(Suppl1), 401.
London, R. S., Bradley, L., & Chiamori, N. Y. (1991). Effect of a nutritional supplement on premenstrual symptomatology in women with premenstrual syndrome: a double-blind longitudinal study. Journal of the American College of Nutrition, 10(5), 494-499.
Quaranta, S., Buscaglia, M. A., Meroni, M. G., Colombo, E., & Cella, S. (2007). Pilot study of the efficacy and safety of a modified-release magnesium 250mg tablet (Sincromag®) for the treatment of premenstrual syndrome. Clinical drug investigation, 27(1), 51-58.
De Souza, M. C., Walker, A. F., Robinson, P. A., & Bolland, K. (2000). A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. Journal of women’s health & gender-based medicine, 9(2), 131-139.
Bendich, A. (2000). The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. Journal of the American college of nutrition, 19(1), 3-12.
Facchinetti, F., Borella, P., Sances, G., Fioroni, L., Nappi, R. E., & Genazzani, A. R. (1991). Oral magnesium successfully relieves premenstrual mood changes. Obstetrics and gynecology, 78(2), 177–181.
Walker, A. F., De Souza, M. C., Vickers, M. F., Abeyasekera, S., Collins, M. L., & Trinca, L. A. (1998). Magnesium supplementation alleviates premenstrual symptoms of fluid retention. Journal of women’s health, 7(9), 1157–1165. https://doi.org/10.1089/jwh.1998.7.1157
Chollet, D., Franken, P., Raffin, Y., Henrotte, J. G., Widmer, J., Malafosse, A., & Tafti, M. (2001). Magnesium involvement in sleep: genetic and nutritional models. Behavior genetics, 31(5), 413–425. https://doi.org/10.1023/a:1012790321071
Held, K., Antonijevic, I. A., Künzel, H., Uhr, M., Wetter, T. C., Golly, I. C., Steiger, A., & Murck, H. (2002). Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry, 35(4), 135–143. https://doi.org/10.1055/s-2002-33195
Lopez-Ridaura, R., Willett, W. C., Rimm, E. B., Liu, S., Stampfer, M. J., Manson, J. E., & Hu, F. B. (2004). Magnesium intake and risk of type 2 diabetes in men and women. Diabetes care, 27(1), 134–140. https://doi.org/10.2337/diacare.27.1.134
Larsson, S. C., & Wolk, A. (2007). Magnesium intake and risk of type 2 diabetes: a meta-analysis. Journal of internal medicine, 262(2), 208–214. https://doi.org/10.1111/j.1365-2796.2007.01840.x
Rodríguez-Morán, M., Simental Mendía, L. E., Zambrano Galván, G., & Guerrero-Romero, F. (2011). The role of magnesium in type 2 diabetes: a brief based-clinical review. Magnesium research, 24(4), 156–162. https://doi.org/10.1684/mrh.2011.0299
Kim, D. J., Xun, P., Liu, K., Loria, C., Yokota, K., Jacobs, D. R., Jr, & He, K. (2010). Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. Diabetes care, 33(12), 2604–2610. https://doi.org/10.2337/dc10-0994
Nielsen F. H. (2014). Effects of magnesium depletion on inflammation in chronic disease. Current opinion in clinical nutrition and metabolic care, 17(6), 525–530. https://doi.org/10.1097/MCO.0000000000000093
Barbagallo, M., & Dominguez, L. J. (2010). Magnesium and aging. Current pharmaceutical design, 16(7), 832–839. https://doi.org/10.2174/138161210790883679
Nielsen F. H. (2010). Magnesium, inflammation, and obesity in chronic disease. Nutrition reviews, 68(6), 333–340. https://doi.org/10.1111/j.1753-4887.2010.00293.x
Nielsen, F. H., Johnson, L. K., & Zeng, H. (2010). Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnesium research, 23(4), 158–168. https://doi.org/10.1684/mrh.2010.0220
Chacko, S. A., Sul, J., Song, Y., Li, X., LeBlanc, J., You, Y., Butch, A., & Liu, S. (2011). Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. The American journal of clinical nutrition, 93(2), 463–473. https://doi.org/10.3945/ajcn.110.002949
Zinc
Siahbazi, S., Behboudi‐Gandevani, S., Moghaddam‐Banaem, L., & Montazeri, A. (2017). Effect of zinc sulfate supplementation on premenstrual syndrome and health‐related quality of life: Clinical randomized controlled trial. Journal of Obstetrics and Gynaecology Research, 43(5), 887-894.
Eby, G. A. (2007). Zinc treatment prevents dysmenorrhea. Medical Hypotheses, 69(2), 297-301.
Sangestani, G., Khatiban, M., Marci, R., & Piva, I. (2015). The positive effects of zinc supplements on the improvement of primary dysmenorrhea and premenstrual symptoms: a double-blind, randomized, controlled trial. Journal of Midwifery and Reproductive Health, 3(3), 378-384.
Zekavat, O. R., Karimi, M. Y., Amanat, A., & Alipour, F. (2015). A randomised controlled trial of oral zinc sulphate for primary dysmenorrhoea in adolescent females. Australian and New Zealand Journal of Obstetrics and Gynaecology, 55(4), 369-373.
Teimoori, B., Ghasemi, M., Hoseini, Z. S., & Razavi, M. (2016). The Efficacy of Zinc Administration in the Treatment of Primary Dysmenorrhea. Oman medical journal, 31(2), 107–111. https://doi.org/10.5001/omj.2016.21
Bao, B., Prasad, A. S., Beck, F. W., Fitzgerald, J. T., Snell, D., Bao, G. W., Singh, T., & Cardozo, L. J. (2010). Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. The American journal of clinical nutrition, 91(6), 1634–1641. https://doi.org/10.3945/ajcn.2009.28836
Prasad, A. S. (2014). Zinc is an antioxidant and anti-inflammatory agent: its role in human health. Frontiers in nutrition, 1, 14.
Bae, Y. S., Hill, N. D., Bibi, Y., Dreiher, J., & Cohen, A. D. (2010). Innovative uses for zinc in dermatology. Dermatologic clinics, 28(3), 587–597. https://doi.org/10.1016/j.det.2010.03.006
Rostami Mogaddam, M., Safavi Ardabili, N., Maleki, N., & Soflaee, M. (2014). Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris. BioMed research international, 2014, 474108. https://doi.org/10.1155/2014/474108
Momen-Heravi, M., Barahimi, E., Razzaghi, R., Bahmani, F., Gilasi, H. R., & Asemi, Z. (2017). The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 25(3), 512–520. https://doi.org/10.1111/wrr.12537
Desneves, K. J., Todorovic, B. E., Cassar, A., & Crowe, T. C. (2005). Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial. Clinical nutrition (Edinburgh, Scotland), 24(6), 979–987. https://doi.org/10.1016/j.clnu.2005.06.011
Hemilä H. (2017). Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM open, 8(5), 2054270417694291. https://doi.org/10.1177/2054270417694291
Haase, H., & Rink, L. (2009). The immune system and the impact of zinc during aging. Immunity & ageing : I & A, 6, 9. https://doi.org/10.1186/1742-4933-6-9
Phytoestrogens
Gossell-Williams, M., Hyde, C., Hunter, T., Simms-Stewart, D., Fletcher, H., McGrowder, D., & Walters, C. A. (2011). Improvement in HDL cholesterol in postmenopausal women supplemented with pumpkin seed oil: pilot study. Climacteric : the journal of the International Menopause Society, 14(5), 558–564. https://doi.org/10.3109/13697137.2011.563882
Richter, D., Abarzua, S., Chrobak, M., Vrekoussis, T., Weissenbacher, T., Kuhn, C., Schulze, S., Kupka, M. S., Friese, K., Briese, V., Piechulla, B., Makrigiannakis, A., Jeschke, U., & Dian, D. (2013). Effects of phytoestrogen extracts isolated from pumpkin seeds on estradiol production and ER/PR expression in breast cancer and trophoblast tumor cells. Nutrition and cancer, 65(5), 739–745. https://doi.org/10.1080/01635581.2013.797000
Xanthopoulou, M. N., Nomikos, T., Fragopoulou, E., & Antonopoulou, S. (2009). Antioxidant and lipoxygenase inhibitory activities of pumpkin seed extracts. Food Research International, 42(5-6), 641-646.
Zaineddin, A. K., Buck, K., Vrieling, A., Heinz, J., Flesch-Janys, D., Linseisen, J., & Chang-Claude, J. (2012). The association between dietary lignans, phytoestrogen-rich foods, and fiber intake and postmenopausal breast cancer risk: a German case-control study. Nutrition and cancer, 64(5), 652–665. https://doi.org/10.1080/01635581.2012.683227
Sesame seeds
Sesame seeds may be small but they are a real nutritional powerhouse since they are packed with variety of nutrients ranging from lignans, vitamin B1, calcium, magnesium, zinc, selenium, and other beneficial compounds.
Lignans (Sesamin, Sesamol, Pinoresinol)
Yavari, M., Rouholamn, S., Tansaz, M., Bioos, S., & Esmaeili, S. (2014). Sesame a treatment of menstrual bleeding cessation in iranian traditional medicine: Results from a pilot study. Shiraz e med J, 15(3), e21893.i
Bedell, S., Nachtigall, M., & Naftolin, F. (2014). The pros and cons of plant estrogens for menopause. The Journal of steroid biochemistry and molecular biology, 139, 225–236. https://doi.org/10.1016/j.jsbmb.2012.12.004
Wu, W. H., Kang, Y. P., Wang, N. H., Jou, H. J., & Wang, T. A. (2006). Sesame ingestion affects sex hormones, antioxidant status, and blood lipids in postmenopausal women. The Journal of nutrition, 136(5), 1270–1275. https://doi.org/10.1093/jn/136.5.1270
Majdalawieh, A. F., Massri, M., & Nasrallah, G. K. (2017). A comprehensive review on the anti-cancer properties and mechanisms of action of sesamin, a lignan in sesame seeds (Sesamum indicum). European journal of pharmacology, 815, 512–521. https://doi.org/10.1016/j.ejphar.2017.10.020
Majdalawieh, A. F., & Mansour, Z. R. (2019). Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action. European journal of pharmacology, 855, 75–89. https://doi.org/10.1016/j.ejphar.2019.05.008
Coulman, K. D., Liu, Z., Hum, W. Q., Michaelides, J., & Thompson, L. U. (2005). Whole sesame seed is as rich a source of mammalian lignan precursors as whole flaxseed. Nutrition and cancer, 52(2), 156–165. https://doi.org/10.1207/s15327914nc5202_6
Cooney, R. V., Custer, L. J., Okinaka, L., & Franke, A. A. (2001). Effects of dietary sesame seeds on plasma tocopherol levels. Nutrition and cancer, 39(1), 66–71. https://doi.org/10.1207/S15327914nc391_9
Ostlund R. E., Jr (2004). Phytosterols and cholesterol metabolism. Current opinion in lipidology, 15(1), 37–41. https://doi.org/10.1097/00041433-200402000-00008
Rogi, T., Tomimori, N., Ono, Y., & Kiso, Y. (2011). The mechanism underlying the synergetic hypocholesterolemic effect of sesamin and α-tocopherol in rats fed a high-cholesterol diet. Journal of pharmacological sciences, 115(3), 408–416. https://doi.org/10.1254/jphs.10287fp
Rogi, T., Tomimori, N., Ono, Y., & Kiso, Y. (2011). The mechanism underlying the synergetic hypocholesterolemic effect of sesamin and α-tocopherol in rats fed a high-cholesterol diet. Journal of pharmacological sciences, 115(3), 408–416. https://doi.org/10.1254/jphs.10287fp
Wichitsranoi, J., Weerapreeyakul, N., Boonsiri, P., Settasatian, C., Settasatian, N., Komanasin, N., Sirijaichingkul, S., Teerajetgul, Y., Rangkadilok, N., & Leelayuwat, N. (2011). Antihypertensive and antioxidant effects of dietary black sesame meal in pre-hypertensive humans. Nutrition journal, 10, 82. https://doi.org/10.1186/1475-2891-10-82
Wikul, A., Damsud, T., Kataoka, K., & Phuwapraisirisan, P. (2012). (+)-Pinoresinol is a putative hypoglycemic agent in defatted sesame (Sesamum indicum) seeds though inhibiting α-glucosidase. Bioorganic & medicinal chemistry letters, 22(16), 5215–5217. https://doi.org/10.1016/j.bmcl.2012.06.068
Haidari, F., Mohammadshahi, M., Zarei, M., & Gorji, Z. (2016). Effects of Sesame Butter (Ardeh) versus Sesame Oil on Metabolic and Oxidative Stress Markers in Streptozotocin-Induced Diabetic Rats. Iranian journal of medical sciences, 41(2), 102–109.
Monteiro, E. M., Chibli, L. A., Yamamoto, C. H., Pereira, M. C., Vilela, F. M., Rodarte, M. P., Pinto, M. A., do Amaral, M., Silvério, M. S., Araújo, A. L., de Araújo, A., Del-Vechio-Vieira, G., & de Sousa, O. V. (2014). Antinociceptive and anti-inflammatory activities of the sesame oil and sesamin. Nutrients, 6(5), 1931–1944. https://doi.org/10.3390/nu6051931
Li, L., Piao, H., Zheng, M., Jin, Z., Zhao, L., & Yan, G. (2016). Sesamin attenuates allergic airway inflammation through the suppression of nuclear factor-kappa B activation. Experimental and therapeutic medicine, 12(6), 4175–4181. https://doi.org/10.3892/etm.2016.3903
Ahmad, S., ElSherbiny, N. M., Jamal, M. S., Alzahrani, F. A., Haque, R., Khan, R., Zaidi, S. K., AlQahtani, M. H., Liou, G. I., & Bhatia, K. (2016). Anti-inflammatory role of sesamin in STZ induced mice model of diabetic retinopathy. Journal of neuroimmunology, 295-296, 47–53. https://doi.org/10.1016/j.jneuroim.2016.04.002
Narasimhulu, C. A., Selvarajan, K., Burge, K. Y., Litvinov, D., Sengupta, B., & Parthasarathy, S. (2016). Water-Soluble Components of Sesame Oil Reduce Inflammation and Atherosclerosis. Journal of medicinal food, 19(7), 629–637. https://doi.org/10.1089/jmf.2015.0154
Narasimhulu, C. A., Selvarajan, K., Litvinov, D., & Parthasarathy, S. (2015). Anti-atherosclerotic and anti-inflammatory actions of sesame oil. Journal of medicinal food, 18(1), 11–20. https://doi.org/10.1089/jmf.2014.0138
Kiran, K., & Asad, M. (2008). Wound healing activity of Sesamum indicum L seed and oil in rats. Indian journal of experimental biology, 46(11), 777.
Calcium
Saeedian Kia, A., Amani, R., & Cheraghian, B. (2015). The Association between the Risk of Premenstrual Syndrome and Vitamin D, Calcium, and Magnesium Status among University Students: A Case Control Study. Health promotion perspectives, 5(3), 225–230. https://doi.org/10.15171/hpp.2015.027
Abdi, F., Ozgoli, G., & Rahnemaie, F. S. (2019). A systematic review of the role of vitamin D and calcium in premenstrual syndrome. Obstetrics & gynecology science, 62(2), 73–86. https://doi.org/10.5468/ogs.2019.62.2.73
Bertone-Johnson, E. R., Hankinson, S. E., Bendich, A., Johnson, S. R., Willett, W. C., & Manson, J. E. (2005). Calcium and vitamin D intake and risk of incident premenstrual syndrome. Archives of internal medicine, 165(11), 1246–1252. https://doi.org/10.1001/archinte.165.11.1246
Whelan, A. M., Jurgens, T. M., & Naylor, H. (2009). Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review. The Canadian journal of clinical pharmacology = Journal canadien de pharmacologie clinique, 16(3), e407–e429.
North American Menopause Society (2006). The role of calcium in peri- and postmenopausal women: 2006 position statement of the North American Menopause Society. Menopause (New York, N.Y.), 13(6), 862–880. https://doi.org/10.1097/01.gme.0000243566.25205.0b
Dawson-Hughes, B., Dallal, G. E., Krall, E. A., Sadowski, L., Sahyoun, N., & Tannenbaum, S. (1990). A controlled trial of the effect of calcium supplementation on bone density in postmenopausal women. The New England journal of medicine, 323(13), 878–883. https://doi.org/10.1056/NEJM199009273231305
Lin, J., Manson, J. E., Lee, I. M., Cook, N. R., Buring, J. E., & Zhang, S. M. (2007). Intakes of calcium and vitamin D and breast cancer risk in women. Archives of internal medicine, 167(10), 1050–1059. https://doi.org/10.1001/archinte.167.10.1050
Cui, Y., & Rohan, T. E. (2006). Vitamin D, calcium, and breast cancer risk: a review. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 15(8), 1427–1437. https://doi.org/10.1158/1055-9965.EPI-06-0075
Bérubé, S., Diorio, C., Mâsse, B., Hébert-Croteau, N., Byrne, C., Côté, G., Pollak, M., Yaffe, M., & Brisson, J. (2005). Vitamin D and calcium intakes from food or supplements and mammographic breast density. Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 14(7), 1653–1659. https://doi.org/10.1158/1055-9965.EPI-05-0068
Magnesium
Facchinetti, F., Sances, G., Borella, P., Genazzani, A. R., & Nappi, G. (1991). Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache: The Journal of Head and Face Pain, 31(5), 298-301.
Allais, G., Gabellari, I. C., Burzio, C., Rolando, S., De Lorenzo, C., Mana, O., & Benedetto, C. (2012). Premenstrual syndrome and migraine. Neurological Sciences, 33(1), 111-115.
Fathizadeh, N., Ebrahimi, E., Valiani, M., Tavakoli, N., & Yar, M. H. (2010). Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iranian Journal of Nursing and Midwifery Research, 15(Suppl1), 401.
London, R. S., Bradley, L., & Chiamori, N. Y. (1991). Effect of a nutritional supplement on premenstrual symptomatology in women with premenstrual syndrome: a double-blind longitudinal study. Journal of the American College of Nutrition, 10(5), 494-499.
Quaranta, S., Buscaglia, M. A., Meroni, M. G., Colombo, E., & Cella, S. (2007). Pilot study of the efficacy and safety of a modified-release magnesium 250mg tablet (Sincromag®) for the treatment of premenstrual syndrome. Clinical drug investigation, 27(1), 51-58.
De Souza, M. C., Walker, A. F., Robinson, P. A., & Bolland, K. (2000). A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. Journal of women’s health & gender-based medicine, 9(2), 131-139.
Bendich, A. (2000). The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. Journal of the American college of nutrition, 19(1), 3-12.
Facchinetti, F., Borella, P., Sances, G., Fioroni, L., Nappi, R. E., & Genazzani, A. R. (1991). Oral magnesium successfully relieves premenstrual mood changes. Obstetrics and gynecology, 78(2), 177–181.
Walker, A. F., De Souza, M. C., Vickers, M. F., Abeyasekera, S., Collins, M. L., & Trinca, L. A. (1998). Magnesium supplementation alleviates premenstrual symptoms of fluid retention. Journal of women’s health, 7(9), 1157–1165. https://doi.org/10.1089/jwh.1998.7.1157
Chollet, D., Franken, P., Raffin, Y., Henrotte, J. G., Widmer, J., Malafosse, A., & Tafti, M. (2001). Magnesium involvement in sleep: genetic and nutritional models. Behavior genetics, 31(5), 413–425. https://doi.org/10.1023/a:1012790321071
Held, K., Antonijevic, I. A., Künzel, H., Uhr, M., Wetter, T. C., Golly, I. C., Steiger, A., & Murck, H. (2002). Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry, 35(4), 135–143. https://doi.org/10.1055/s-2002-33195
Lopez-Ridaura, R., Willett, W. C., Rimm, E. B., Liu, S., Stampfer, M. J., Manson, J. E., & Hu, F. B. (2004). Magnesium intake and risk of type 2 diabetes in men and women. Diabetes care, 27(1), 134–140. https://doi.org/10.2337/diacare.27.1.134
Larsson, S. C., & Wolk, A. (2007). Magnesium intake and risk of type 2 diabetes: a meta-analysis. Journal of internal medicine, 262(2), 208–214. https://doi.org/10.1111/j.1365-2796.2007.01840.x
Rodríguez-Morán, M., Simental Mendía, L. E., Zambrano Galván, G., & Guerrero-Romero, F. (2011). The role of magnesium in type 2 diabetes: a brief based-clinical review. Magnesium research, 24(4), 156–162. https://doi.org/10.1684/mrh.2011.0299
Kim, D. J., Xun, P., Liu, K., Loria, C., Yokota, K., Jacobs, D. R., Jr, & He, K. (2010). Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. Diabetes care, 33(12), 2604–2610. https://doi.org/10.2337/dc10-0994
Nielsen F. H. (2014). Effects of magnesium depletion on inflammation in chronic disease. Current opinion in clinical nutrition and metabolic care, 17(6), 525–530. https://doi.org/10.1097/MCO.0000000000000093
Barbagallo, M., & Dominguez, L. J. (2010). Magnesium and aging. Current pharmaceutical design, 16(7), 832–839. https://doi.org/10.2174/138161210790883679
Nielsen F. H. (2010). Magnesium, inflammation, and obesity in chronic disease. Nutrition reviews, 68(6), 333–340. https://doi.org/10.1111/j.1753-4887.2010.00293.x
Nielsen, F. H., Johnson, L. K., & Zeng, H. (2010). Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnesium research, 23(4), 158–168. https://doi.org/10.1684/mrh.2010.0220
Chacko, S. A., Sul, J., Song, Y., Li, X., LeBlanc, J., You, Y., Butch, A., & Liu, S. (2011). Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. The American journal of clinical nutrition, 93(2), 463–473. https://doi.org/10.3945/ajcn.110.002949
Zinc
Siahbazi, S., Behboudi‐Gandevani, S., Moghaddam‐Banaem, L., & Montazeri, A. (2017). Effect of zinc sulfate supplementation on premenstrual syndrome and health‐related quality of life: Clinical randomized controlled trial. Journal of Obstetrics and Gynaecology Research, 43(5), 887-894.
Eby, G. A. (2007). Zinc treatment prevents dysmenorrhea. Medical Hypotheses, 69(2), 297-301.
Sangestani, G., Khatiban, M., Marci, R., & Piva, I. (2015). The positive effects of zinc supplements on the improvement of primary dysmenorrhea and premenstrual symptoms: a double-blind, randomized, controlled trial. Journal of Midwifery and Reproductive Health, 3(3), 378-384.
Zekavat, O. R., Karimi, M. Y., Amanat, A., & Alipour, F. (2015). A randomised controlled trial of oral zinc sulphate for primary dysmenorrhoea in adolescent females. Australian and New Zealand Journal of Obstetrics and Gynaecology, 55(4), 369-373.
Teimoori, B., Ghasemi, M., Hoseini, Z. S., & Razavi, M. (2016). The Efficacy of Zinc Administration in the Treatment of Primary Dysmenorrhea. Oman medical journal, 31(2), 107–111. https://doi.org/10.5001/omj.2016.21
Bao, B., Prasad, A. S., Beck, F. W., Fitzgerald, J. T., Snell, D., Bao, G. W., Singh, T., & Cardozo, L. J. (2010). Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. The American journal of clinical nutrition, 91(6), 1634–1641. https://doi.org/10.3945/ajcn.2009.28836
Prasad, A. S. (2014). Zinc is an antioxidant and anti-inflammatory agent: its role in human health. Frontiers in nutrition, 1, 14.
Bae, Y. S., Hill, N. D., Bibi, Y., Dreiher, J., & Cohen, A. D. (2010). Innovative uses for zinc in dermatology. Dermatologic clinics, 28(3), 587–597. https://doi.org/10.1016/j.det.2010.03.006
Rostami Mogaddam, M., Safavi Ardabili, N., Maleki, N., & Soflaee, M. (2014). Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris. BioMed research international, 2014, 474108. https://doi.org/10.1155/2014/474108
Momen-Heravi, M., Barahimi, E., Razzaghi, R., Bahmani, F., Gilasi, H. R., & Asemi, Z. (2017). The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 25(3), 512–520. https://doi.org/10.1111/wrr.12537
Desneves, K. J., Todorovic, B. E., Cassar, A., & Crowe, T. C. (2005). Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial. Clinical nutrition (Edinburgh, Scotland), 24(6), 979–987. https://doi.org/10.1016/j.clnu.2005.06.011
Hemilä H. (2017). Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM open, 8(5), 2054270417694291. https://doi.org/10.1177/2054270417694291
Haase, H., & Rink, L. (2009). The immune system and the impact of zinc during aging. Immunity & ageing : I & A, 6, 9. https://doi.org/10.1186/1742-4933-6-9
Vitamin B1
Chocano-Bedoya, P. O., Manson, J. E., Hankinson, S. E., Willett, W. C., Johnson, S. R., Chasan-Taber, L., Ronnenberg, A. G., Bigelow, C., & Bertone-Johnson, E. R. (2011). Dietary B vitamin intake and incident premenstrual syndrome. The American journal of clinical nutrition, 93(5), 1080–1086. https://doi.org/10.3945/ajcn.110.009530
Zafari, M., Aghamohammady, A., & Tofighi, M. (2011). Comparing the effect of vitamin B1 (vit. B1) and ibuberofen on the treatment of primary dysmenorrhea. Afr J Pharm Pharmacol, 5(7), 874-8.
Gokhale, L. B. (1996). Curative treatment of primary (spasmodic) dysmenorrhoea. The Indian journal of medical research, 103, 227-231.
Abdollahifard, S., & Maddahfar, M. (2016). The effects of vitamin B1 on ameliorating of mental symptoms of the premenstrual syndrome. European Psychiatry, (33), S335.
Almohanna, H. M., Ahmed, A. A., Tsatalis, J. P., & Tosti, A. (2019). The role of vitamins and minerals in hair loss: a review. Dermatology and therapy, 9(1), 51-70.
Selenium
Rayman, M. P., Thompson, A. J., Bekaert, B., Catterick, J., Galassini, R., Hall, E., Warren-Perry, M., & Beckett, G. J. (2008). Randomized controlled trial of the effect of selenium supplementation on thyroid function in the elderly in the United Kingdom. The American journal of clinical nutrition, 87(2), 370–378. https://doi.org/10.1093/ajcn/87.2.370
Ventura, M., Melo, M., & Carrilho, F. (2017). Selenium and Thyroid Disease: From Pathophysiology to Treatment. International journal of endocrinology, 2017, 1297658. https://doi.org/10.1155/2017/1297658
Schnabel, R., Lubos, E., Messow, C. M., Sinning, C. R., Zeller, T., Wild, P. S., Peetz, D., Handy, D. E., Munzel, T., Loscalzo, J., Lackner, K. J., & Blankenberg, S. (2008). Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease The SElenium Therapy in Coronary Artery disease Patients (SETCAP) Study. American heart journal, 156(6), 1201.e1–1201.e12011. https://doi.org/10.1016/j.ahj.2008.09.004
Puspitasari, I. M., Abdulah, R., Yamazaki, C., Kameo, S., Nakano, T., & Koyama, H. (2014). Updates on clinical studies of selenium supplementation in radiotherapy. Radiation oncology (London, England), 9, 125. https://doi.org/10.1186/1748-717X-9-125
Cai, X., Wang, C., Yu, W., Fan, W., Wang, S., Shen, N., Wu, P., Li, X., & Wang, F. (2016). Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression. Scientific reports, 6, 19213. https://doi.org/10.1038/srep19213
Hoffmann, P. R., & Berry, M. J. (2008). The influence of selenium on immune responses. Molecular nutrition & food research, 52(11), 1273–1280. https://doi.org/10.1002/mnfr.200700330
Steinbrenner, H., Al-Quraishy, S., Dkhil, M. A., Wunderlich, F., & Sies, H. (2015). Dietary selenium in adjuvant therapy of viral and bacterial infections. Advances in nutrition (Bethesda, Md.), 6(1), 73–82. https://doi.org/10.3945/an.114.007575
Sunflower seeds
Sunflower seeds are loaded with essential vitamins and minerals, including vitamin E and B6, flavonoids, magnesium, zinc and selenium which support your women’s health and make your skin glow.
Vitamin B6
Doll, H., Brown, S., Thurston, A., & Vessey, M. (1989). Pyridoxine (vitamin B6) and the premenstrual syndrome: a randomized crossover trial. The Journal of the Royal College of General Practitioners, 39(326), 364-368.
Kashanian, M., Mazinani, R., Jalalmanesh, S., & Babayanzad Ahari, S. (2007). Pyridoxine (vitamin B6) therapy for premenstrual syndrome. International Journal of Gynecology & Obstetrics, 96(1), 43-44.
Wyatt, K. M., Dimmock, P. W., Jones, P. W., & O’Brien, P. S. (1999). Efficacy of vitamin B-6 in the treatment of premenstrual syndrome: systematic review. Bmj, 318(7195), 1375-1381.
De Souza, M. C., Walker, A. F., Robinson, P. A., & Bolland, K. (2000). A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. Journal of women’s health & gender-based medicine, 9(2), 131-139.
Fathizadeh, N., Ebrahimi, E., Valiani, M., Tavakoli, N., & Yar, M. H. (2010). Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iranian Journal of Nursing and Midwifery Research, 15(Suppl1), 401.
Shobeiri, F., Oshvandi, K., & Nazari, M. (2015). Clinical effectiveness of vitamin E and vitamin B6 for improving pain severity in cyclic mastalgia. Iranian journal of nursing and midwifery research, 20(6), 723–727. https://doi.org/10.4103/1735-9066.170003
Christen, W. G., Glynn, R. J., Chew, E. Y., Albert, C. M., & Manson, J. E. (2009). Folic acid, pyridoxine, and cyanocobalamin combination treatment and age-related macular degeneration in women: the Women’s Antioxidant and Folic Acid Cardiovascular Study. Archives of internal medicine, 169(4), 335–341. https://doi.org/10.1001/archinternmed.2008.574
Sofi, F., Marcucci, R., Bolli, P., Giambene, B., Sodi, A., Fedi, S., Menchini, U., Gensini, G. F., Abbate, R., & Prisco, D. (2008). Low vitamin B6 and folic acid levels are associated with retinal vein occlusion independently of homocysteine levels. Atherosclerosis, 198(1), 223–227. https://doi.org/10.1016/j.atherosclerosis.2007.09.009
Magnesium
Facchinetti, F., Sances, G., Borella, P., Genazzani, A. R., & Nappi, G. (1991). Magnesium prophylaxis of menstrual migraine: effects on intracellular magnesium. Headache: The Journal of Head and Face Pain, 31(5), 298-301.
Allais, G., Gabellari, I. C., Burzio, C., Rolando, S., De Lorenzo, C., Mana, O., & Benedetto, C. (2012). Premenstrual syndrome and migraine. Neurological Sciences, 33(1), 111-115.
Fathizadeh, N., Ebrahimi, E., Valiani, M., Tavakoli, N., & Yar, M. H. (2010). Evaluating the effect of magnesium and magnesium plus vitamin B6 supplement on the severity of premenstrual syndrome. Iranian Journal of Nursing and Midwifery Research, 15(Suppl1), 401.
London, R. S., Bradley, L., & Chiamori, N. Y. (1991). Effect of a nutritional supplement on premenstrual symptomatology in women with premenstrual syndrome: a double-blind longitudinal study. Journal of the American College of Nutrition, 10(5), 494-499.
Quaranta, S., Buscaglia, M. A., Meroni, M. G., Colombo, E., & Cella, S. (2007). Pilot study of the efficacy and safety of a modified-release magnesium 250mg tablet (Sincromag®) for the treatment of premenstrual syndrome. Clinical drug investigation, 27(1), 51-58.
De Souza, M. C., Walker, A. F., Robinson, P. A., & Bolland, K. (2000). A synergistic effect of a daily supplement for 1 month of 200 mg magnesium plus 50 mg vitamin B6 for the relief of anxiety-related premenstrual symptoms: a randomized, double-blind, crossover study. Journal of women’s health & gender-based medicine, 9(2), 131-139.
Bendich, A. (2000). The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. Journal of the American college of nutrition, 19(1), 3-12.
Facchinetti, F., Borella, P., Sances, G., Fioroni, L., Nappi, R. E., & Genazzani, A. R. (1991). Oral magnesium successfully relieves premenstrual mood changes. Obstetrics and gynecology, 78(2), 177–181.
Walker, A. F., De Souza, M. C., Vickers, M. F., Abeyasekera, S., Collins, M. L., & Trinca, L. A. (1998). Magnesium supplementation alleviates premenstrual symptoms of fluid retention. Journal of women’s health, 7(9), 1157–1165. https://doi.org/10.1089/jwh.1998.7.1157
Chollet, D., Franken, P., Raffin, Y., Henrotte, J. G., Widmer, J., Malafosse, A., & Tafti, M. (2001). Magnesium involvement in sleep: genetic and nutritional models. Behavior genetics, 31(5), 413–425. https://doi.org/10.1023/a:1012790321071
Held, K., Antonijevic, I. A., Künzel, H., Uhr, M., Wetter, T. C., Golly, I. C., Steiger, A., & Murck, H. (2002). Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans. Pharmacopsychiatry, 35(4), 135–143. https://doi.org/10.1055/s-2002-33195
Lopez-Ridaura, R., Willett, W. C., Rimm, E. B., Liu, S., Stampfer, M. J., Manson, J. E., & Hu, F. B. (2004). Magnesium intake and risk of type 2 diabetes in men and women. Diabetes care, 27(1), 134–140. https://doi.org/10.2337/diacare.27.1.134
Larsson, S. C., & Wolk, A. (2007). Magnesium intake and risk of type 2 diabetes: a meta-analysis. Journal of internal medicine, 262(2), 208–214. https://doi.org/10.1111/j.1365-2796.2007.01840.x
Rodríguez-Morán, M., Simental Mendía, L. E., Zambrano Galván, G., & Guerrero-Romero, F. (2011). The role of magnesium in type 2 diabetes: a brief based-clinical review. Magnesium research, 24(4), 156–162. https://doi.org/10.1684/mrh.2011.0299
Kim, D. J., Xun, P., Liu, K., Loria, C., Yokota, K., Jacobs, D. R., Jr, & He, K. (2010). Magnesium intake in relation to systemic inflammation, insulin resistance, and the incidence of diabetes. Diabetes care, 33(12), 2604–2610. https://doi.org/10.2337/dc10-0994
Nielsen F. H. (2014). Effects of magnesium depletion on inflammation in chronic disease. Current opinion in clinical nutrition and metabolic care, 17(6), 525–530. https://doi.org/10.1097/MCO.0000000000000093
Barbagallo, M., & Dominguez, L. J. (2010). Magnesium and aging. Current pharmaceutical design, 16(7), 832–839. https://doi.org/10.2174/138161210790883679
Nielsen F. H. (2010). Magnesium, inflammation, and obesity in chronic disease. Nutrition reviews, 68(6), 333–340. https://doi.org/10.1111/j.1753-4887.2010.00293.x
Nielsen, F. H., Johnson, L. K., & Zeng, H. (2010). Magnesium supplementation improves indicators of low magnesium status and inflammatory stress in adults older than 51 years with poor quality sleep. Magnesium research, 23(4), 158–168. https://doi.org/10.1684/mrh.2010.0220
Chacko, S. A., Sul, J., Song, Y., Li, X., LeBlanc, J., You, Y., Butch, A., & Liu, S. (2011). Magnesium supplementation, metabolic and inflammatory markers, and global genomic and proteomic profiling: a randomized, double-blind, controlled, crossover trial in overweight individuals. The American journal of clinical nutrition, 93(2), 463–473. https://doi.org/10.3945/ajcn.110.002949
Vitamin E
Shobeiri, F., Oshvandi, K., & Nazari, M. (2015). Clinical effectiveness of vitamin E and vitamin B6 for improving pain severity in cyclic mastalgia. Iranian journal of nursing and midwifery research, 20(6), 723–727. https://doi.org/10.4103/1735-9066.170003
Pruthi, S., Wahner-Roedler, D. L., Torkelson, C. J., Cha, S. S., Thicke, L. S., Hazelton, J. H., & Bauer, B. A. (2010). Vitamin E and evening primrose oil for management of cyclical mastalgia: a randomized pilot study. Alternative Medicine Review, 15(1), 59.
Parsay, S., Olfati, F., & Nahidi, S. (2009). Therapeutic effects of vitamin E on cyclic mastalgia. The breast journal, 15(5), 510-514.
Shobeiri, F., Oshvandi, K., & Nazari, M. (2015). Clinical effectiveness of vitamin E and vitamin B6 for improving pain severity in cyclic mastalgia. Iranian journal of nursing and midwifery research, 20(6), 723–727. https://doi.org/10.4103/1735-9066.170003
Ziaei, S., Kazemnejad, A., & Sedighi, A. (2008). The effect of vitamin E on the treatment of menstrual migraine. Medical Science Monitor, 15(1), CR16-CR19.
Kashanian, M., Lakeh, M. M., Ghasemi, A., & Noori, S. (2013). Evaluation of the effect of vitamin E on pelvic pain reduction in women suffering from primary dysmenorrhea. The Journal of reproductive medicine, 58(1-2), 34-38.
Ziaei, S., Zakeri, M., & Kazemnejad, A. (2005). A randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoea. BJOG: An International Journal of Obstetrics & Gynaecology, 112(4), 466-469.
Bendich, A. (2000). The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. Journal of the American college of nutrition, 19(1), 3-12.
Pandel, R., Poljšak, B., Godic, A., & Dahmane, R. (2013). Skin photoaging and the role of antioxidants in its prevention. ISRN dermatology, 2013, 930164. https://doi.org/10.1155/2013/930164
Packer, L., & Valacchi, G. (2002). Antioxidants and the response of skin to oxidative stress: vitamin E as a key indicator. Skin pharmacology and applied skin physiology, 15(5), 282–290. https://doi.org/10.1159/000064531
Packer, L., Weber, S. U., & Rimbach, G. (2001). Molecular aspects of alpha-tocotrienol antioxidant action and cell signalling. The Journal of nutrition, 131(2), 369S–73S. https://doi.org/10.1093/jn/131.2.369S
Boelsma, E., Hendriks, H. F., & Roza, L. (2001). Nutritional skin care: health effects of micronutrients and fatty acids. The American journal of clinical nutrition, 73(5), 853–864. https://doi.org/10.1093/ajcn/73.5.853
Burke, K. E., Clive, J., Combs, G. F., Jr, Commisso, J., Keen, C. L., & Nakamura, R. M. (2000). Effects of topical and oral vitamin E on pigmentation and skin cancer induced by ultraviolet irradiation in Skh:2 hairless mice. Nutrition and cancer, 38(1), 87–97. https://doi.org/10.1207/S15327914NC381_13
Zinc
Siahbazi, S., Behboudi‐Gandevani, S., Moghaddam‐Banaem, L., & Montazeri, A. (2017). Effect of zinc sulfate supplementation on premenstrual syndrome and health‐related quality of life: Clinical randomized controlled trial. Journal of Obstetrics and Gynaecology Research, 43(5), 887-894.
Eby, G. A. (2007). Zinc treatment prevents dysmenorrhea. Medical Hypotheses, 69(2), 297-301.
Sangestani, G., Khatiban, M., Marci, R., & Piva, I. (2015). The positive effects of zinc supplements on the improvement of primary dysmenorrhea and premenstrual symptoms: a double-blind, randomized, controlled trial. Journal of Midwifery and Reproductive Health, 3(3), 378-384.
Zekavat, O. R., Karimi, M. Y., Amanat, A., & Alipour, F. (2015). A randomised controlled trial of oral zinc sulphate for primary dysmenorrhoea in adolescent females. Australian and New Zealand Journal of Obstetrics and Gynaecology, 55(4), 369-373.
Teimoori, B., Ghasemi, M., Hoseini, Z. S., & Razavi, M. (2016). The Efficacy of Zinc Administration in the Treatment of Primary Dysmenorrhea. Oman medical journal, 31(2), 107–111. https://doi.org/10.5001/omj.2016.21
Bao, B., Prasad, A. S., Beck, F. W., Fitzgerald, J. T., Snell, D., Bao, G. W., Singh, T., & Cardozo, L. J. (2010). Zinc decreases C-reactive protein, lipid peroxidation, and inflammatory cytokines in elderly subjects: a potential implication of zinc as an atheroprotective agent. The American journal of clinical nutrition, 91(6), 1634–1641. https://doi.org/10.3945/ajcn.2009.28836
Prasad, A. S. (2014). Zinc is an antioxidant and anti-inflammatory agent: its role in human health. Frontiers in nutrition, 1, 14.
Bae, Y. S., Hill, N. D., Bibi, Y., Dreiher, J., & Cohen, A. D. (2010). Innovative uses for zinc in dermatology. Dermatologic clinics, 28(3), 587–597. https://doi.org/10.1016/j.det.2010.03.006
Rostami Mogaddam, M., Safavi Ardabili, N., Maleki, N., & Soflaee, M. (2014). Correlation between the severity and type of acne lesions with serum zinc levels in patients with acne vulgaris. BioMed research international, 2014, 474108. https://doi.org/10.1155/2014/474108
Momen-Heravi, M., Barahimi, E., Razzaghi, R., Bahmani, F., Gilasi, H. R., & Asemi, Z. (2017). The effects of zinc supplementation on wound healing and metabolic status in patients with diabetic foot ulcer: A randomized, double-blind, placebo-controlled trial. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society, 25(3), 512–520. https://doi.org/10.1111/wrr.12537
Desneves, K. J., Todorovic, B. E., Cassar, A., & Crowe, T. C. (2005). Treatment with supplementary arginine, vitamin C and zinc in patients with pressure ulcers: a randomised controlled trial. Clinical nutrition (Edinburgh, Scotland), 24(6), 979–987. https://doi.org/10.1016/j.clnu.2005.06.011
Hemilä H. (2017). Zinc lozenges and the common cold: a meta-analysis comparing zinc acetate and zinc gluconate, and the role of zinc dosage. JRSM open, 8(5), 2054270417694291. https://doi.org/10.1177/2054270417694291
Haase, H., & Rink, L. (2009). The immune system and the impact of zinc during aging. Immunity & ageing : I & A, 6, 9. https://doi.org/10.1186/1742-4933-6-9
Flavonoids
Guo, S., Ge, Y., & Na Jom, K. (2017). A review of phytochemistry, metabolite changes, and medicinal uses of the common sunflower seed and sprouts (Helianthus annuus L.). Chemistry Central journal, 11(1), 95. https://doi.org/10.1186/s13065-017-0328-7
Linoleic acid
Nunes, D. O., Marques, V. B., Almenara, C., Marcarini, W. D., Ribeiro Júnior, R. F., & Padilha, A. S. (2018). Linoleic acid reduces vascular reactivity and improves the vascular dysfunction of the small mesentery in hypertension. The Journal of nutritional biochemistry, 62, 18–27. https://doi.org/10.1016/j.jnutbio.2018.07.016
Richmond, K., Williams, S., Mann, J., Brown, R., & Chisholm, A. (2012). Markers of cardiovascular risk in postmenopausal women with type 2 diabetes are improved by the daily consumption of almonds or sunflower kernels: a feeding study. ISRN nutrition, 2013, 626414. https://doi.org/10.5402/2013/626414
Selenium
Rayman, M. P., Thompson, A. J., Bekaert, B., Catterick, J., Galassini, R., Hall, E., Warren-Perry, M., & Beckett, G. J. (2008). Randomized controlled trial of the effect of selenium supplementation on thyroid function in the elderly in the United Kingdom. The American journal of clinical nutrition, 87(2), 370–378. https://doi.org/10.1093/ajcn/87.2.370
Ventura, M., Melo, M., & Carrilho, F. (2017). Selenium and Thyroid Disease: From Pathophysiology to Treatment. International journal of endocrinology, 2017, 1297658. https://doi.org/10.1155/2017/1297658
Schnabel, R., Lubos, E., Messow, C. M., Sinning, C. R., Zeller, T., Wild, P. S., Peetz, D., Handy, D. E., Munzel, T., Loscalzo, J., Lackner, K. J., & Blankenberg, S. (2008). Selenium supplementation improves antioxidant capacity in vitro and in vivo in patients with coronary artery disease The SElenium Therapy in Coronary Artery disease Patients (SETCAP) Study. American heart journal, 156(6), 1201.e1–1201.e12011. https://doi.org/10.1016/j.ahj.2008.09.004
Puspitasari, I. M., Abdulah, R., Yamazaki, C., Kameo, S., Nakano, T., & Koyama, H. (2014). Updates on clinical studies of selenium supplementation in radiotherapy. Radiation oncology (London, England), 9, 125. https://doi.org/10.1186/1748-717X-9-125
Cai, X., Wang, C., Yu, W., Fan, W., Wang, S., Shen, N., Wu, P., Li, X., & Wang, F. (2016). Selenium Exposure and Cancer Risk: an Updated Meta-analysis and Meta-regression. Scientific reports, 6, 19213. https://doi.org/10.1038/srep19213
Hoffmann, P. R., & Berry, M. J. (2008). The influence of selenium on immune responses. Molecular nutrition & food research, 52(11), 1273–1280. https://doi.org/10.1002/mnfr.200700330
Steinbrenner, H., Al-Quraishy, S., Dkhil, M. A., Wunderlich, F., & Sies, H. (2015). Dietary selenium in adjuvant therapy of viral and bacterial infections. Advances in nutrition (Bethesda, Md.), 6(1), 73–82. https://doi.org/10.3945/an.114.007575
Organic • Raw • Vegan • Gluten-free • High in fibre • No added sugar
3 Dates
1 Tsp Of Dried Mango
1 Tbsp Of Sesame Seeds
1/3 Tsp Of Maca Powder
1 Tbsp Of Sunflower Seeds
2 Drops Of Natural Mango Flavour
3 Tsp Of Desiccated Coconut
1/10 Pinch Of Salt
1 Tsp Of Dried Pineapple
Dates* (39%), sunflower seeds* (16%), sesame seeds* (16%), coconut desiccated* (10%), dried pineapple* (9%), dried mango* (8%), maca powder*, natural mango flavour* (0,2%), salt.
*Organic certified ingredient.
We use only raw natural ingredients so they preserve all their vitamins and minerals. Here is a list of what one bar contain:
Organic • Raw • Vegan • Gluten-free • High in fibre • No added sugar
3 Dates
2 Tbs Of Cacao Nibs
1 Tbsp Of Sesame Seeds
1/3 Tsp Of Maca Powder
1 Tbsp Of Sunflower Seeds
1/10 Tsp Of Turmeric Powder
15 Raisins
1/3 Pinch Of Black Pepper
2 Tbs Of Cacao Powder
1/2 Drop Of Natural Orange Flavour
Dates* (37%), sunflower seeds* (16%), sesame seeds* (16%), raisins* (raisins*, sunflower oil*), cacao powder* (9%), cacao nibs* (9%), maca powder* (2%), turmeric powder* (0,6%), black pepper powder*, natural orange flavor* (0,05%).
*Organic certified ingredient.
We use only raw natural ingredients so they preserve all their vitamins and minerals. Here is a list of what one bar contain:
Organic • Raw • Vegan • Gluten-free • High in fibre • No added sugar
3 Dates
1 Tsp Of Cacao Nibs
1 Tbsp Of Flax Seeds
9 Raisins
1 Tbsp Of Pumpkin Seeds
1/3 Tsp Of Chokeberry Powder
15 Dried Cranberries
1/4 Tsp Of Baobab Powder
1 Tsp Of Cacao Powder
1/10 Pinch Of Salt
Dates* (36%), flax seeds* (18%), pumpkin seeds* (14%), cranberries* (cranberries*, apple juice concentrate*, sunflower oil*) (10%), cacao powder* (7%), cacao nibs* (6%), raisins* (raisins*, sunflower oil*), chokeberry powder* (1,6%), baobab powder*, salt.
*Organic certified ingredient.
We use only raw natural ingredients so they preserve all their vitamins and minerals. Here is a list of what one bar contain:
Organic • Raw • Vegan • Gluten-free • High in fibre • No added sugar
3 Dates
6 Raisins
1 Tbsp Of Flax Seeds
1/3 Tsp Of Chokeberry Powder
1 Tbsp Of Pumpkin Seeds
1/3 Tsp Of Baobab Powder
9 Dried Cranberries
6 Drops Of Bourbon Vanilla Extract
4 Freeze-Dried Strawberries
2 Drops Of Natural Cherry Flavour
4 Freeze-Dried Raspberries
1/10 Pinch of Salt
Dates* (41%), pumpkin seeds* (20%), flax seeds* (20%), cranberries* (cranberries*, apple juice concentrate*, sunflower oil*) (6%), Freez-dried mix of berries* (strawberries*, raspberries*) (5%), raisins* (raisins*, sunflower oil*), chokeberry powder* (1,8%), baobab powder* (1,7), bourbon vanilla* (0,6%), natural cherry flavour*, salt.
*Organic certified ingredient.
We use only raw natural ingredients so they preserve all their vitamins and minerals. Here is a list of what one bar contain:
